Product Specification: Ethyl Butylacetylaminopropionate 99% TC

Chemical Name: Ethyl N-acetyl-N-butyl-β-alaninate
Common Name: Ethyl Butylacetylaminopropionate
Other Names: IR3535
CAS Number: 52304-36-6
Molecular Formula: C₁₁H₂₁NO₃
Molecular Weight: 215.29 g/mol
Purity: ≥99.0% (by GC or HPLC)
Formulation Type: Technical Concentrate (TC)

Description:

Ethyl Butylacetylaminopropionate 99% TC is a high-purity technical-grade insect repellent ingredient known commercially as IR3535. It is a synthetic repellent structurally derived from naturally occurring amino acids and is widely used in personal care products and public health formulations to repel biting insects such as mosquitoes, ticks, flies, and lice.

This compound is non-greasy, has a mild odor, and is considered safe and well-tolerated by the skin, making it suitable for use in lotions, sprays, creams, and other topical formulations. IR3535 is recognized by the World Health Organization (WHO) and various regulatory agencies for its excellent safety profile and broad-spectrum repellency.

Physical and Chemical Properties:

• Appearance: Clear, colorless to pale yellow liquid

• Odor: Mild and non-irritating

• Boiling Point: ~130–140°C at 0.1 mmHg

• Flash Point: >100°C (closed cup)

• Density (20°C): ~1.01 g/cm³

• Solubility: Miscible with ethanol and other cosmetic solvents; slightly soluble in water

• Vapor Pressure (20°C): Low (<1 Pa)

• Stability: Chemically stable under normal conditions; not light-sensitive; pH stable across a wide range

• Shelf Life: Minimum 2 years in original packaging

Specification Parameters:

• Active Ingredient Content: ≥99.0%

• Water Content (Karl Fischer): ≤0.5%

• Acidity (as Acetic Acid): ≤0.2%

• Impurities: Conform to technical-grade purity limits

• Appearance: Clear liquid, free from visible impurities

Applications:

Ethyl Butylacetylaminopropionate 99% TC is used as the active ingredient in:

• Insect repellent creams, sprays, gels, and wipes

• Personal care products (skin lotions, cosmetics)

• Outdoor protection formulations (repellent wristbands, patches)

• Pet care and veterinary products

• Clothing treatments and textiles

Target Organisms:

• Mosquitoes (Aedes, Anopheles, Culex)

• Ticks, flies, lice, midges, fleas

Its efficacy is comparable to DEET, with better skin tolerance and minimal environmental impact. It is suitable for use on children and sensitive skin, making it ideal for consumer-friendly formulations.

Mode of Action:

Ethyl Butylacetylaminopropionate functions as a behavioral modifier for insects. It interferes with the insects' ability to locate human hosts by disrupting olfactory receptors, thereby preventing bites. Unlike neurotoxic insecticides, it does not kill insects but acts as a spatial repellent, reducing vector contact and disease transmission.

Toxicological Profile:

• Oral LD₅₀ (rat): >5,000 mg/kg (very low toxicity)

• Dermal LD₅₀ (rat): >5,000 mg/kg

• Irritation/Sensitization: Non-irritant to skin and eyes; non-sensitizing

• Mutagenicity/Carcinogenicity: Not mutagenic or carcinogenic

• Biodegradability: Readily biodegradable

• Ecotoxicity: Low toxicity to aquatic organisms; not bioaccumulative

Packaging and Storage:

• Standard Packaging: 25 kg HDPE drums or 200 kg plastic-lined steel drums

• Storage Conditions: Store in a cool, dry, and well-ventilated area; protect from direct sunlight and high temperatures

• Handling: Use gloves and eye protection; follow good manufacturing practices

Regulatory Approvals:

• Approved by EU, US EPA, WHO, and various national health agencies

• Compliant with cosmetic and biocide regulations

• Safe for use in children’s and sensitive skin products